Respiratory diseases as lifestyle-related diseases

[Lifestyle related diseases in children and adolescents].

1.小児・思春期生活習慣病の概念(表 1) 本来成人病の概念は,死亡原因から癌,心臓病,脳 卒中など,有病率から高血圧,2型糖尿病,高脂血症, 肥満など,疾患を早期に発見・治療する「2次予防」に 重点をおいたものであった.一方,小児・思春期成人 病の概念は,成人病が小児・思春期に発症したもの, またはその起源が小児期にあると考えられる疾患とし て,疾患の発生を予防する「1次予防」に重点を置いて きた.すなわち,silent disease である動脈硬化を引き 起こすであろう疾患である高脂血症,高血圧,2型糖尿 病,肥満などであり,有病率からみた成人病の概念に 一致する. 1996 年,厚生省から「成人病」から「生活習慣病」へ の改称が提唱された.最初違和感があったこの呼び名 も定着しつつある.生活習慣病の概念は,小児・思春 期成人病と同様に「1次予防」に主眼をおいたものであ り,そ...

NO-Rich Diet for Lifestyle-Related Diseases

Decreased nitric oxide (NO) availability due to obesity and endothelial dysfunction might be causally related to the development of lifestyle-related diseases such as insulin resistance, ischemic heart disease, and hypertension. In such situations, instead of impaired NO synthase (NOS)-dependent NO generation, the entero-salivary nitrate-nitrite-NO pathway might serve as a backup system for NO ...

3 - B ~ E . Asbestos - Related Respiratory Diseases

Biomedical and Lifestyle Diseases

Integrins as Therapeutic Targets for Respiratory Diseases

Integrins are a large family of transmembrane heterodimeric proteins that constitute the main receptors for extracellular matrix components. Integrins were initially thought to be primarily involved in the maintenance of cell adhesion and tissue integrity. However, it is now appreciated that integrins play important roles in many other biological processes such as cell survival, proliferation, ...